We performed univariable statistics to identify factors associated with positive margins and then logistic regression modeling on significant factors for the outcome of positive margins. Cuello et al. Cervical cone biopsies are performed with either a laser or surgical blade (cold knife) and result in a conical excision of cervical tissue centered on the os. But my period has been weird lately, and I've suddenly … We calculated the Odds Ratio (OR) of women with peristent HPV 16 infection and positive margin, to have a recurrence. In short, based on these results, patients with positive and negative LEEP findings should be treated and followed up similarly. The purpose of this study was to determine if colposcopy with biopsy is necessary following a high‐grade Pap smear before treatment decision, and also to identify risk factors associated with an increased risk of … Auto text: “Insert Leep Cone” Background. The result of the follow-up colposcopy was not found to be significantly different based upon initial margin status (p=0.19), grade of dysplasia at the margin (p=0.3), or 3 depth of excision (p=0.8). It really wasn't bad at all. Recurrence rate for the median follow‐up time of 2 … It is also argued that the tissue margins in a LEEP biopsy may show significant thermal artefact, which can interfere with the pathological assessment of biopsy margins.5 6 Some studies have shown a greater risk of a positive endocervical margin with LEEP but these have included cases in which AIS was not suspected prior to the excisional procedure.7–9 However, current … A procedure called a loop excision electrocautery procedure (aka LEEP) may be indicated when a patient receives an abnormal Pap smear result, usually after visualizing the cervix and/or lesion with colposcopy.. Pap smear histology is graded on a scale of negative, ASC-US, CIN 1, CIN 2, and CIN 3. Among patients who had re-LEEP or conization (n=46), 7 patients (15,2%) had still positive surgical margine after the second procedure (5 in re-LEEP … Results from second LEEP; Abnormal Pap after second LEEP; SECOND LEEP; Just made an appointment for my second LEEP... preparing for my second LEEP Cervical cone biopsies and LEEPs (loop electrosurgical excision procedure) are both performed to remove pre-cancerous lesions from the cervix. A multivariable model was not attempted as LEEP margin status and LEEP biopsy result are strongly related. The results showed that high-risk factors of positive ECC during follow-up were as follows: 1. positive ECC before LEEP, 2. involved margins of LEEP, 3. high-risk HPV infection during follow-up, and 4. abnormal LCT during follow-up. Positive LEEP surgical margin was found in 167 cases (30.5 %). My gynecologist is now recommending hysterectomy and I'm just wondering if there are any other options. The CIN grades, particularly 2 and 3, may indicate an … Furthermore, when the one-piece and two-piece LEEP specimens were analysed separately, the one-piece LEEP specimens had a significantly higher rate of positive margins (81.0%) compared with CKC (34.2%), but there was no significant difference in the rate of positive margins between two-piece LEEP (50.0%) and CKC (34.2%). I took an Ibuprfen for very light pain. Says its more accurate than a Leep.. Feb 2021: Surgery-Cold Knife Cone & re-testing for HPV. First, we found that a positive ECC before LEEP indicated a risk for positive ECC during follow-up (OR = 1.670). However, … greenbean22: Cancer: Cervical & Ovarian: 7: 11-16-2003 12:35 PM: Positive Margins on Leep Results: kmas: Cancer: Cervical & Ovarian: 4: 10-14-2003 10:55 PM « Hello, I'm new, just had LEEP done for carcinoma in situ | … Furthermore, the HPV 16 positive women with a negative margin, de- veloped 8 recurrences (40%). Ectocervical or endocervical margins were negative after repeat LEEP conization in the majority of women, except for 2 patients (3.6%) with CIN 3 and positive ectocervical margins. A positive ECC has traditionally been an indication to perform a cold-knife conization or LEEP–Cone. Women with hr HPV but whose margin … LEEP (loop electrosurgical excisional procedure) is one way to remove abnormal cells from the cervix by using a thin wire loop that acts like a scalpel (surgical knife). First of all - I am so thankful for this message board and all of the support … Does cin3 take long time to get since first infection of hpv Had a leep, results came back CIN3 with no clear margins. From this study it was found that the persistence of genotype 16 is … The persistence rate among women with positive LEEP specimen margins was higher than among women with negative margins. By continuing to browse this site you are agreeing to our use of cookies. RESULTS: Two hundred … Had a leep, results came back CIN3 with no clear margins. Additionally, 2 multivariate analysis using the covariates listed above found no significant factors. Posts: 36 Positive Margins on Leep Results. 10-25% of LEEPs performed for a diagnosis of high grade squamous dysplasia will show recurrence of a high grade lesion during the subsequent follow up, regardless of the presence of dysplasia within the excision specimen (assuming adequate … {{configCtrl2.info.metaDescription}} This site uses cookies. Results: In our study, the rate of persistent infection from HPV 16, after LEEP, was 15.9% (29/182) with 94% (17/18) of the recurring disease occurring within 18 months of follow up. I had a LEEP 6 years ago that turned up positive margins. status and 16 with a positive margin status on their initial LEEP. The risk of residual disease (abnormal cells that are left behind in the cervix after the LEEP) is reported to be as high as 25 percent when LEEP margins are positive, as opposed to 11 percent with negative margins… We performed univariable statistics to identify factors associated with positive margins and then logistic regression modeling on significant factors for the outcome of positive margins . Of these, 13 (87%) women had positive findings on follow-up, and 2 (13%) … Doc recommended a Cold Knife Cone. If combined with an HPV test, it is of some value for the prognosis of this disease. 145/227 were confirmed as having CIN in the LEEP specimen. In summary, the positive incisal margin following LEEP operation is linked to relapse of the disease. When my doc told me there wasn't a treatment plan for eradicating the virus, I about shat myself. It only took about 30 minutes and they gave me a general anesthesia. So, he did an in-office biopsy and sent the tissue he got from my cervix and the lab results came back as dysplasia (HPV) positive - CIN 1. HPV test at … Of the 182 patients positive at the HPV test at T0 (be-fore LEEP), 144 (79.1%) were negative at 6months (T1) ... cases) with positive margin and 16 HPV positive have developed a recurrence (100%), while the hr HPV pa-tients (6 cases) only relapsed in one case. Indications for LEEP. Women whose LEEP biopsy specimen had positive margins were significantly more likely to have residual HSIL on follow-up than women whose specimens had negative margins (Table 1). 11 found significant recurrence associated with positive endocervical, but not ectocervical margins. The oncology surgeon who followed up with me after that told me to give it two months, then we'd do a pap and see how it went. These results suggest that a larger LEEP (i.e., a two-piece LEEP … LEEP (loop electrosurgical excision procedure) is the preferred method of diagnosis and treatment of high-grade cervical intraepithelial neoplasia (CIN). There was no associ-ation between the treatment performed, the volume of the surgical specimen, and recurrence with negative or positive margins (p> 0.05). The positive margin of LEEP specimen especially the cone top status was a significant risk factor for residual/recurrent disease after LEEP. When performing the LEEP operation, the lesion tissue should … 50.0% (33/66) of the patients with positive margins on the first pass had dysplasia or worse (CIN I–III or CA) in the second pass (top hat), compared to 6.6% (12/182) of the patients with a negative first pass (P < 0.0001). Positive endocervical margins were associated with a higher rate of persistence than positive ectocervical margins. I've been diagnosed with cervical dysplasia (loop electrosurgical excision procedure), CIN 2/3 and had both LEEP and conization done with still positive margins (all this in less than a year after a normal Pap smear). A positive margin was defined as HSIL on either the endocervical or ectocervical margin of the LEEP specimen or in endocervical curettage specimen after LEEP. I was terrified when diagnosed with High Risk HPV. Therefore, after the operation, the high risk of the same sub-type HPV may indicate the future development of the CIN lesion. Join Date: Oct 2003. Conclusion Conservative treatment is an option in the treat-ment of AIS, for patients who desire fertility-sparing treat … When LEEP margins are positive, there is a higher likelihood that abnormal cells are left behind in the cervix, when compared to when the margins are negative. Multivariate logistic analysis showed that age, positive margins, abnormal cytology, and positive hrHPV during follow-up … Univariate analysis found CIN III on histology and parity to be predictive of dysplasia in the top … Well, it turned out ok. And I had 3-month checkups for a year or two, then 6-month PAPs ever since then, and each one has been clear. In addition to positive endocervical margins, 15 patients also had positive deep margins. I've heard many negatives about that surgery in … Positive Margins on Leep Results; Positive Margins on Leep Results : Subscribe To Cancer: Cervical & Ovarian Thread Tools: Search this Thread: 10-14-2003, 08:11 AM #1: kmas Junior Member . These specimens are … Hi all! These traditional indications were evaluated in this study to assess the presence of dysplasia in the top hat and dysplasia found at the margin of resection in LEEP or LEEP–Cone specimens. Patients had follow‐up at three month intervals with Pap smears and indicated colposcopy/biopsy. Among 79 margin positive cases, 33 (41.7%) had re-LEEP, 13 (16.5%) had cold-knife conization, 13 (16.5%) had hysterectomy, and 12 (15.1%) were just followed-up while 8 (10.2%) were lost to follow up after the LEEP procedure. An electric current is passed through a wire loop … What is the next step? LEEP at CIN II/ III with positive margins-- recurrence of second leep?! We calculated the Odds Ratio (OR) of women with peristent HPV 16 infection and positive margin, to have a recurrence. In our study, the rate of persistent infection from HPV 16, after LEEP, was 15.9% (29/182) with 94% (17/18) of the recurring disease occurring within 18 months of follow up. TODAY: CLEAR MARGINS (YAYYYYYYY) NEGATIVE HPV. … LEEP and conization were performed under colposcopic guide in local anesthesia in an outpatient facility by experienced personnel []; loops of different sizes were used according to lesion’s characteristics and cervix conformation; in all cases, care was taken to personalize the loop size.Excision margins were kept 2-3 mm out of the lesion, and completeness of lesion’s … Post Second LEEP; i had my second leep oct 17 and just got the results; has anyone had a second LEEP? men (in mm3) in the LEEP procedure (p = 0.033) and the positive surgical margin (p =0.012). 66/145 (45%) had involved (positive) margins, and 79/145 (55%) had noninvolved (negative) margins. Objective: The study was performed to determine whether the human papillomavirus (HPV) genotype result from the HPV DNA chip test (HDC) was predictive of recurrent high-grade cervical intraepithelial neoplasia (CIN2-3) in patients with positive margins after a loop electrosurgical excision procedure (LEEP).Methods: A total of 184 patients with histologically confirmed … A total of 248 women underwent LEEP–Cone. Tested positive for 8 high risk strains including 16. LEEP margin status was also strongly related to HSIL on histology at week 26 or 52 with this occurring in 39 of 91 (49.9%) women with LEEP margins positive for HSIL compared with 16 of 62 (19.5%) women without this result (OR, 3.1 [95% CI, 1.56–6.14]; P = .0013). Positive margins - Normal Post-Leep Pap: kmas: Cancer: Cervical & Ovarian: 3: 12-06-2003 07:33 AM: had a leep, clear margins still worry?? After LEEP, Brockmeyer et al. 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