I like the way the writers focused a lot on the researchers but interweaving Elizabeth Hughes story. Over this time span I've been fortunate to watch a gradual development in our understanding of the science and treatment of diabetes that looked at cumulatively has been truly remarkable. Please try again. This work of non-fiction follows the true story of eleven-year-old Elizabeth Hughes, who was diagnosed with juvenile diabetes in 1919. Just two weeks shy of her 60th birthday she went in for triple bypass surgery and didn't come out. It also analyzes reviews to verify trustworthiness. Informative and humbling to know how recent the control has been established. Working as a paediatric endocrinologist this book gives a fascinating insight into the years of the discovery of insulin and individual families struck by diabetes. Eli Lilly's family is now firmly on a pedestal in my mind. Finnish researchers are about to embark on the first-ever clinical trial for a … There is information about Diabetes and the standard treat. The book chronicles the successes and failures along the way, and does a brief summary of the revolution provided by Genentech’s creation of a recombinant form of insulin. There was no cure and few survived more than a year. Since I enjoy historical fiction, this was an easy book to read because the authors took poetic license here and there to create drama in the story. The story has been "augmented" for narrative purposes. St. Martin's Griffin; Reprint edition (October 25, 2011). This was an amazing insight into the discovery, testing, and production of the Insulin. In Stock. Interesting that even back in the 20s you had to have money for decent medical care (if it wasn't for her dads power and influence she wouldn't have gone on insulin). I read this book because I just took a job in a diabetes business unit and wanted--as a layman--to learn more about the disease the therapy. We’d love your help. It is 1919 and Elizabeth Hughes, the eleven-year-old daughter of America's most-distinguished jurist and politician, Charles Evans Hughes, has been diagnosed with juvenile diabetes. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others. Expert reaction. This book provides an interesting historical narrative of the discovery and the dramatic personalities who, by chance, combined to discover a treatment which continues to save millions of lives every day. The breakthrough in treatment for type 1 diabetes was welcomed by medics and health associations. I know that not everyone will be interested in the discovery of insulin but this is a great book for those who are. Goodreads helps you keep track of books you want to read. ISBN: 9781469153247. Dr. Allen worked with these children and while some said it was wrong to prolong their lives by subjecting them to starvation, he did keep many of them alive to receive treatment. Fortunately [..] for millions of children, he knew next to nothing.”, “Insulin was now not only readily available, but also affordable. Top subscription boxes – right to your door, © 1996-2020, Amazon.com, Inc. or its affiliates. Bring your club to Amazon Book Clubs, start a new book club and invite your friends to join, or find a club that’s right for you for free. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. It is essentially a death sentence. The authors disclose this practice, so there is no deception, and I believe that it does make the story-telling flow better than admitting that the authors had to hypothesize what had happened. “Banting’s initial idea was neither original nor successful, but he persisted in it, and his persistence led to a solution that was both original and successful. Reviewed in the United States on July 27, 2019. I've been around quite a while, having graduated medical school in 1964. Third, there's the ultimate ability to distribute insulin to people with diabetes everywhere, and this part of the story is full of shocks and surprises, difficulties and heartaches, and even fistfights! Breakthrough is the fascinating tale of Nobel prize-winning research, of a young girl who should have died as a child but instead lived to see seven grandchildren, and of a drug that turned a death sentence into something more akin to a chronic nuisance. "The twentieth century witnessed many medical miracles, but perhaps none was so transformative as the discovery of insulin for the treatment for diabetes. Also I find it hard to honor Lilly that made and makes untold millions from insulin. Breakthrough brings to life the human side of one of the most important discoveries in modern medicine, the discovery of insulin. An excellent book if you're looking for an impartial recount. interesting book, lots of interesting history on the discovery of insulin, Reviewed in the United States on June 25, 2017. It tells the events that went down during the discovery, the feuds that went down between the original team of discoverers, the greatly debated Nobel prize and the story of Elizabeth Hughes. I am sorry that Elizabeth Hughes chose to hide her diabetes and declined to support research in her bequests. Please try again. As a story, the plot and characters were well-drawn and flowed nicely. It is the discovery of insulin, by Canadian researchers Frederick Banting and Charles Best, that saves her life—and the lives of diabetics around the world. Reviewed in the United States on January 15, 2016. I was familiar (a little) with the subject of Banting & Best, but to see them through this book as people not just names was an interesting experience. The complete title of the book is BREAKTHROUGH: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle, and to me there are many miracles in this story. I do not see how she successfully hid her disease from her fiance until after they were engaged, did not tell her children and lived for so many years without telling people about it. In Stock. Please try again. It may have made the story more appealing to others but that was at the expense of its integrity. This quote kind of sums up the blood, sweat and tears this man, and many others working with him, put into the discovery and production of insulin in Toronto, Canada 1918-1922. This also goes over the politics in America during that time, which isn't something I think is relevant to the discovery of insulin. The book tells the story of the discovery of insulin and everyone that has been instrumental to it in a very attractive way. By. Understanding the sheer mass of of pancreas needed to purify insulin is stunning; more than 2 tons are needed to purify 8 ounces of insulin. This book put a real face on the misery of patients who had Diabetes 1, which is juvenile diabetes (think Mary Tyler Moore). Apr 26, 2012 - Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle [Cooper, Thea, Ainsberg, Arthur] on Amazon.com. Ships from and sold by Amazon.com. Andy Corbley - Nov 20, 2020. “The twentieth century witnessed many medical miracles, but perhaps none was so transformative as the discovery of insulin for the treatment for diabetes. I don't feel like I have to talk about it all the time, but a lot of times it is easier to just explain. From the starvation of patients under Dr. Allen who hoped to only keep them alive until a cure could be found to the testing of pancreas glands of various animals in Canada that led to the development of insulin this book shows how it all came together. Like Teddy Ryder's birthday story where Banting comes in dressed in a pink dress. And I liked the focus on Elizabeth Hughes. Elizabeth's weight eventually dropped below 50 lbs, and many wondered if the treatment wasn't worse than the disease. Fascinating story with several prominent early 20th c. people involved and an Indianapolis connection through Eli Lilly. There are very few medical stories that can match it. Profiles several fascinating historical figures, including Charles Evans Hughes -- famous New York lawyer who was governor of New York, ran for President and sat on the Supreme Court, and who's daughter had Type 1 diabetes. Deserves wider readership, recommended as s starter for anyone wanting to get to grips with this exciting part of history. It's an unimaginable choice to have to make and the odds were terrible. Some of the descriptions are heart rending. Reviewed in the United States on August 18, 2016. The protein behind Type 2 diabetes has finally been caught in the act, and could lead to a breakthrough in treatment. An enjoyable fictionalized account of the discovery of insulin and Elizabeth Hughes' experience as a diabetes patient in the pre- and post-insulin periods. I only recommend this to people who like biographies and American politics after the first World War. The Discovery of Insulin: Twenty-fifth Anniversary Edition by Michael Bliss Paperback $34.00. Bit boring to read in parts. I had no idea how the discovery of insulin and how to make it and use it happened. Her guilt was more important than the millions of children and adults that came after her. By gradually decreasing the caloric intake to control blood-glucose levels, he managed to keep patients alive longer in the belief that a cure was imminent. While this book is essentially nonfiction. York insulin chemists in anniversary breakthrough. Profiles several fascinating historical figures, including Charles Evans Hughes -- famous New York lawyer who was governor of New York, ran for President and sat on the Supreme Court, and who's daughter had Type 1 diabetes. I felt like I was being cheated. If within the first 60 days of receipt you are not satisfied with The Diabetes Breakthrough, you can request a refund by sending an email to the ClickBank email address given inside the product and ClickBank® will immediately refund your entire purchase price, with no questions asked. Until we can nail down a cure, there will always been a need to … Prior to its discovery the diagnosis of Type 1 diabetes was a death sentence. I realize that I might be the only one interested in reading this book about the discovery of insulin, but if you've ever known or know someone who needs to take insulin to stay alive, this book is fascinating! There was a number of years where scientists knew that sugar and the pancreas was involved but attempts to reliably produce insulin and replicate results were disheartening. There was an error retrieving your Wish Lists. It is 1919 and Elizabeth Hughes, the eleven-year-old daughter of America's most-distinguished jurist and politician, Charles Evans Hughes, has been diagnosed with juvenile diabetes. It is 1919 and Elizabeth Hughes, the eleven-year-old daughter of America's most-distinguished jurist and politician, Charles Evans Hughes, has been diagnosed with juvenile diabetes. Very good book, could not put it down. At the time, diabetes was a death sentence with the only treatment being starvation, which only served to pr. The culprit was calcified veins a result of having diabetes for so long. Such an amazing story about the history of insulin and those who created and refined the formula. I thought this would be more of a book about the science, the clinical trials, and the push for production of insulin. I vaguely realized that before insulin diabetes was fatal, but I hadn't really put too much thought into it. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. Be the first to ask a question about Breakthrough. It was nice to get kind of a "wrap up" in the last few pages of how everyone in the book ended out. This book … I can't imagine what it must have been like for what was probably the majority of children who didn't have her advantages. Without regular injections of insulin, people with type one diabetes become seriously ill and eventually fall into a coma and die. by St. Martin's Press. Nothing however could possibly match the drama of the initial development and use of insulin. It would have been more compelling if Elizabeth Hughes had not destroyed most of the record of her childhood diabetes--apparently she was determined to be "normal"--she lived to 72-- and only her closest relatives knew she was diabetic. She could have been a powerful voice! Second, there's the unbelievable result that insulin provided to real-life historic figures who were on death's door, weak and starving, but were rejuvenated due to insulin. Breakthrough is the fascinating tale of Nobel prize-winning research, of a young girl who should have died as a child but instead lived to see seven grandchildren, and of a drug that turned a death sentence into something more akin to a chronic nuisance. Your recently viewed items and featured recommendations, Select the department you want to search in, Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle. I only recommend this to people who like biographies and American politics after the first World War. In a race against time and a ravaging disease, Elizabeth becomes one of the first diabetics to receive insulin injections - all while its discoverers and a little known pharmaceutical company struggle to make it available to the rest of the world. Definitely deserving of the Noble Prize. Cooper and Ainsberg clearly did a ton of research and usually did a good job of working it in organically (every so often there was an irrelevant fact or digression). If you want to see what all the fuss is about and to take part in the breakthrough against type 2 diabetes, join our Low Carb Program which, we are very proud to say, has been a game-changer in improving thousands of people’s lives since it launched in 2015. At the time, diabetes was a death sentence with the only treatment being starvation, which only served to prolong a child's life. First, there's the discovery itself, which took place in a dirty lab in Toronto under the most unlikely summer conditions. Vista previa de Apple Books. Breakthrough brings to life the human side of one of the most important discoveries in modern medicine, the discovery of insulin. Scientists in the north-east of England have made a seismic breakthrough in the long-running quest to cure diabetes . Category: Medical. Her struggle is kind of an inspiration. Use the Amazon App to scan ISBNs and compare prices. This book is an important read for anyone with diabetes. It covers the fights (including fistfights) of the development team in Canada and the mass production that would make Eli L. Breakthrough provides an excellent look at the business, political, scientific and human side of the race to find insulin. I often thank God for those who contributed to the discovery of insulin and all the tools that go along with managing diabetes, but now I have names for my prayers. It was hard to start and keep going on but once I had some dedicated time to read I couldn't put it down. It was one of the 20th century's medical miracles, and with this retelling of the discovery of insulin (10 months after Caroline Cox's The Fight to Survive: A Young Girl, Diabetes, and the Discovery of Insulin) it's a gripping narrative as well. Dr. Shallenberger’s new book, The Type 2 Diabetes Breakthrough, was released by Health Publications in February 2006, and has received many rave reviews from both patients and physicians. Heard about this on WFYI publc radio show "Sound Medicine." There was a problem loading your book clubs. The keystone for the book is Elizabeth Hughes, a young girl diagnosed with diabetes, and daughter of the politician and jurist, Charles Evan Hughes. We certainly have no way of knowing what exactly went through Banting's head as this or that happened. The book describes the early pioneer in the U.S. of severe dietary restriction to keep diabetics alive, Frederick Allen, and then moves forward to the research efforts to understand diabetes in animal models, primarily through the work of Frederick Banting and Charles Best in th. I was also impressed that two people could have such a coherent shared writing "voice. The authors follow the scientists who discovered how to extract, use and distribute insulin, and also weave the story of a girl with diabetes and an influential mother and father. Title: Breakthrough: Elizabeth Hughes, the Discovery of Insulin, and the Making of a Medical Miracle Published by: St. Martin's Press Buy the Book: Amazon, Apple Books, Barnes & Noble, IndieBound Overview. There was a number of years where scientists knew that sugar and the pancreas was involved but attempts to reliably produce insulin and replicate results were disheartening. Elizabeth was the daughter of one of the most well known politicians of the time, Charles Evans Hughes. (Less than 100 years ago.) Even with the vastly improved diagnostic, testing and dosing techniques, I find it difficult to "not tell." Now I have read The Discovery of Insulin by Micheal G. Bliss. Reviewed in the United Kingdom on December 12, 2012. Relive the heartwarming true story of the discovery of insulin as it's never been told before. I did not know that the method of dealing with those who were diabetic was to basically put them on a starvation diet. This is a story that is very close to my heart. I am a physician specializing in diabetes treatment. One man came up with a starvation diet that could only promise to stave off death for months, occasionally for a year or so. Es un buen libro a nivel de divulgación sobre el impacto que tuvo el descubrimiento de la insulina en las vidas de las personas con Diabetes tipo 1. You'll notice that there's a lot of touch ups that the autohors felt necessary to fill in gaps. Some problems in children with diabetes are still the same! Why did she go to so much effort to hide or deny her diabetes? Page: 240. Back then at the turn of the 20th century, there was nothing that could be done. I know that not everyone will be interested in the discovery of insulin but this is a great book for those who are. Publisher: Xlibris Corporation. Gift of modern medicine diabetes are still the breakthrough book insulin am very disappointed to say that i,... And percentage breakdown by star, we don ’ t use a average! 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